When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication ...

HOUSTON – (Aug. 9, 2022) – Knowing the structure of a complex biological system isn’t nearly enough to understand how it works. It helps to know how the system moves. In that light, Rice University ...

Cancer isn't just about broken genes—it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off ...

Researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in host cells. University ...

A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Researchers have modeled a key mechanism by which DNA replicates. The study could help identify new targets to treat disease. Knowing the structure of a complex biological system isn't nearly enough ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

The Nobel prize in chemistry has gone to research showing how DNA fixes the damage that can cause cancer and premature ageing. Tomas Lindahl of the Francis Crick Institute in Hertfordshire, UK, Paul ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break-when both sides of the DNA helix are cut at once.

The first 100 bases of many genes show excess mutations, revealing a major genomic weak spot that shapes disease risk and ...